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KMID : 0624620230560010002
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BMB Reports
2023 Volume.56 No. 1 p.2 ~ p.9
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Aging of hair follicle stem cells and their niches
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Jang Han-Saem
Jo Ye-Min
Lee Jung-Hyun
Choi Se-Kyu
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Abstract
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Hair follicles in the skin undergo cyclic rounds of regeneration, degeneration, and rest throughout life. Stem cells residing in hair follicles play a pivotal role in maintaining tissue homeostasis and hair growth cycles. Research on hair follicle aging and age-related hair loss has demonstrated that a decline in hair follicle stem cell (HFSC) activity with aging can decrease the regeneration capacity of hair follicles. This review summarizes our understanding of how age-associated HFSC intrinsic and extrinsic mechanisms can induce HFSC aging and hair loss. In addition, we discuss approaches developed to attenuate age-associated changes in HFSCs and their niches, thereby promoting hair regrowth.
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KEYWORD
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Adult stem cell, Aging, Hair follicle, Skin stem cell, Stem cell niche
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